Using the article by von Eye and colleagues as a springboard, this commentary considers a variety of challenges to valid exploration of mediation processes. Along the way, a several alternatives for reinserting the individual back into mediation processes are entertained. The configural frequency approach to mediation analyses proposed by von Eye et al. (Integrative Psychological & Behavioral Science 43(3), 2009) represents a major step toward this objective. Idiographic approaches are proposed as the next step in the progression toward individual-centered mediation analyses.