Psychiatric and cognitive phenotype in children and adolescents with myotonic dystrophy

Eur Child Adolesc Psychiatry. 2009 Dec;18(12):705-15. doi: 10.1007/s00787-009-0037-4. Epub 2009 Jun 19.

Abstract

Myotonic dystrophy type 1 (DM1) is the most frequent inherited neuromuscular disorder. The juvenile form has been associated with cognitive and psychiatric dysfunction, but the phenotype remains unclear. We reviewed the literature to examine the psychiatric phenotype of juvenile DM1 and performed an admixture analysis of the IQ distribution of our own patients, as we hypothesised a bimodal distribution. Two-thirds of the patients had at least one DSM-IV diagnosis, mainly attention deficit/hyperactivity disorder and anxiety disorder. Two-thirds had learning disabilities comorbid with mental retardation on one hand, but also attention deficit, low cognitive speed and visual spatial impairment on the other. IQ showed a bi-modal distribution and was associated with parental transmission. The psychiatric phenotype in juvenile DM1 is complex. We distinguished two different phenotypic subtypes: one group characterised by mental retardation, severe developmental delay and maternal transmission; and another group characterised by borderline full scale IQ, subnormal development and paternal transmission.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adolescent
  • Anxiety Disorders / diagnosis
  • Anxiety Disorders / genetics
  • Anxiety Disorders / psychology
  • Attention Deficit Disorder with Hyperactivity / genetics
  • Attention Deficit Disorder with Hyperactivity / psychology*
  • Child
  • Child Behavior Disorders / diagnosis
  • Child Behavior Disorders / genetics
  • Child Behavior Disorders / psychology*
  • Child Development Disorders, Pervasive / diagnosis
  • Child Development Disorders, Pervasive / genetics
  • Child Development Disorders, Pervasive / psychology*
  • Child, Preschool
  • Comorbidity
  • Depressive Disorder / diagnosis
  • Depressive Disorder / genetics
  • Depressive Disorder / psychology
  • Female
  • Genetic Carrier Screening
  • Genotype
  • Humans
  • Intellectual Disability / diagnosis
  • Intellectual Disability / genetics
  • Intellectual Disability / psychology*
  • Intelligence / genetics*
  • Internal-External Control*
  • Male
  • Myotonic Dystrophy / genetics
  • Myotonic Dystrophy / psychology*
  • Phenotype*
  • Self-Injurious Behavior / genetics
  • Self-Injurious Behavior / psychology
  • Young Adult