High transmissibility of the modern Beijing Mycobacterium tuberculosis in homeless patients of Japan

Takayuki Wada; Sami Fujihara; Akira Shimouchi; Makoto Harada; Hisashi Ogura; Sohkichi Matsumoto; Atsushi Hase

doi:10.1016/j.tube.2009.05.007

High transmissibility of the modern Beijing Mycobacterium tuberculosis in homeless patients of Japan

Tuberculosis (Edinb). 2009 Jul;89(4):252-5. doi: 10.1016/j.tube.2009.05.007. Epub 2009 Jul 9.

Authors

Takayuki Wada¹, Sami Fujihara, Akira Shimouchi, Makoto Harada, Hisashi Ogura, Sohkichi Matsumoto, Atsushi Hase

Affiliation

¹ Department of Microbiology, Osaka City Institute of Public Health and Environmental Sciences, 8-34 Tojo-cho, Tennoji-ku, Osaka 543-0026, Japan. taka-wada@city.osaka.lg.jp

PMID: 19541541
DOI: 10.1016/j.tube.2009.05.007

Abstract

A population-based study of Mycobacterium tuberculosis isolated from homeless tuberculosis patients was performed during 2002-2004 in Osaka City, Japan. The data show that the ancient Beijing subfamily was predominant, whereas clustered isolates based on refined variable number of tandem repeats genotyping (19 loci) mainly belonged to the modern Beijing subfamily, suggesting its increased transmissibility.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Aged, 80 and over
Bacterial Typing Techniques / methods
Cluster Analysis
Female
Genotype
Humans
Ill-Housed Persons*
Japan / epidemiology
Male
Middle Aged
Mycobacterium tuberculosis / classification*
Mycobacterium tuberculosis / genetics
Mycobacterium tuberculosis / isolation & purification
Species Specificity
Tandem Repeat Sequences
Tuberculosis / microbiology*
Tuberculosis / transmission*