A covalently linked phenanthridine-ruthenium(II) complex as a RNA probe

Chem Commun (Camb). 2009 May 21:(19):2640-2. doi: 10.1039/b900290a. Epub 2009 Apr 20.

Abstract

A phenanthridine derivative covalently linked to a ruthenium complex yields an imaging probe whose fluorescence intensity and lifetime change substantially in the presence of RNA.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Breast Neoplasms / metabolism
  • Fluorescent Dyes / chemical synthesis
  • Microscopy, Fluorescence
  • Organometallic Compounds / chemical synthesis*
  • Phenanthridines / chemical synthesis*
  • RNA Probes / chemical synthesis*
  • Ruthenium / chemistry*

Substances

  • Fluorescent Dyes
  • Organometallic Compounds
  • Phenanthridines
  • RNA Probes
  • Ruthenium