Reasons why long-term travel (> or =3 months) increases health risks are many, but mainly related to travellers' behaviour. On top of immunizations proposed to all travellers, those against hepatitis B, rabies and typhoid fever should be encouraged, but require time and money. Some vaccines like meningococcal vaccine and japanese encephalitis need to be discussed according to the destination. Tuberculosis is a rare disease in travellers in general but the incidence in health care workers reaches the one of the local population at risk, and therefore tuberculosis detection is recommended.