Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells

Kei Ohnuma; Masahiko Uchiyama; Ryo Hatano; Wataru Takasawa; Yuko Endo; Nam H Dang; Chikao Morimoto

doi:10.1016/j.bbrc.2009.06.027

Blockade of CD26-mediated T cell costimulation with soluble caveolin-1-Ig fusion protein induces anergy in CD4+T cells

Biochem Biophys Res Commun. 2009 Aug 21;386(2):327-32. doi: 10.1016/j.bbrc.2009.06.027. Epub 2009 Jun 10.

Authors

Kei Ohnuma¹, Masahiko Uchiyama, Ryo Hatano, Wataru Takasawa, Yuko Endo, Nam H Dang, Chikao Morimoto

Affiliation

¹ Department of Rheumatology and Allergy, Research Hospital, The Institute of Medical Science, The University of Tokyo, Shirokanedai, Tokyo 108-8639, Japan.

PMID: 19523449
DOI: 10.1016/j.bbrc.2009.06.027

Abstract

CD26 binds to caveolin-1 in antigen-presenting cells (APC), and that ligation of CD26 by caveolin-1 induces T cell proliferation in a TCR/CD3-dependent manner. We report herein the effects of CD26-caveolin-1 costimulatory blockade by fusion protein caveolin-1-Ig (Cav-Ig). Soluble Cav-Ig inhibits T cell proliferation and cytokine production in response to recall antigen, or allogeneic APC. Our data hence suggest that blocking of CD26-associated signaling by soluble Cav-Ig may be an effective approach as immunosuppressive therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

CD4-Positive T-Lymphocytes / immunology*
Caveolin 1 / immunology*
Cells, Cultured
Clonal Anergy*
Dipeptidyl Peptidase 4 / immunology*
Humans
Immunoglobulin G / immunology*
Immunosuppression Therapy
Lymphocyte Activation
Recombinant Fusion Proteins / immunology*

Substances

Caveolin 1
Immunoglobulin G
Recombinant Fusion Proteins
Dipeptidyl Peptidase 4