It is a fundamental question in neuroscience how long-term memory formation is regulated at the molecular level. Although widely considered a highly complex process requiring numerous molecular players, it also has been speculated that a single protein could play a pivotal role. This "astonishing hypothesis" has made a significant impact on memory research and has led to a reevaluation of concepts regarding memory formation.1,2.
Keywords: AMPA-receptor trafficking; PKMzeta; actin cytoskeleton; long-term memory; long-term potentiation; metaplasticity.