Abstract
The six-membered nitrogen-containing ring of the morphan scaffold, ubiquitous in natural products, is formed by an intramolecular aldol process of an aza-tethered dicarbonyl compound, leading to the first asymmetric synthesis of a morphan derivative using organocatalysis.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aldehydes / chemistry*
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Azabicyclo Compounds / chemical synthesis*
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Azabicyclo Compounds / chemistry
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Catalysis
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Glycine / analogs & derivatives
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Glycine / chemistry
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Ketones / chemistry
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Microwaves*
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Proline / chemistry
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Stereoisomerism
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Substrate Specificity
Substances
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Aldehydes
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Azabicyclo Compounds
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Ketones
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2-aminoacetaldehyde
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3-hydroxybutanal
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Proline
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Glycine