Abstract
2-(1,1-Dioxo-2H-[1,2,4]benzothiadiazin-3-yl)-1-hydroxynaphthalene derivatives as potential anti-HCV drugs targeting NS5B polymerase have been investigated. Their synthesis, HCV NS5B polymerase inhibition and replicon activity are discussed.
MeSH terms
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Animals
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Antiviral Agents / chemical synthesis*
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Antiviral Agents / pharmacology
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Benzothiadiazines / chemical synthesis*
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Benzothiadiazines / pharmacology
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Chemistry, Pharmaceutical / methods
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Drug Design
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Enzyme Inhibitors / chemical synthesis*
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Enzyme Inhibitors / pharmacology
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Hepacivirus / metabolism
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Hepatitis C / drug therapy*
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Humans
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In Vitro Techniques
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Inhibitory Concentration 50
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Magnetic Resonance Spectroscopy
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Models, Chemical
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Molecular Structure
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Naphthalenes / antagonists & inhibitors*
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Naphthalenes / chemistry
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Naphthols / chemical synthesis*
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Naphthols / pharmacology
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Structure-Activity Relationship
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Viral Nonstructural Proteins / antagonists & inhibitors*
Substances
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Antiviral Agents
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Benzothiadiazines
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Enzyme Inhibitors
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Naphthalenes
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Naphthols
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Viral Nonstructural Proteins
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naphthalene
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NS-5 protein, hepatitis C virus