Association between patient age at the time of surgical treatment for endometriosis and aryl hydrocarbon receptor repressor polymorphism

Fertil Steril. 2009 Oct;92(4):1240-1242. doi: 10.1016/j.fertnstert.2009.04.041. Epub 2009 Jun 6.

Abstract

A cross-sectional comparative study among women who underwent surgical treatment for endometriosis revealed that frequency of the Ala/Ala genotype at aryl hydrocarbon receptor repressor (AHRR) Pro185Ala polymorphism was three times higher (27.6% vs. 9.9%) in the younger group (<or=30 years) than in the older group (>30 years). AHHR genotyping may help to identify a subpopulation of women who are susceptible to the earlier onset of endometriosis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Age of Onset
  • Basic Helix-Loop-Helix Transcription Factors
  • Endometriosis / diagnosis
  • Endometriosis / epidemiology*
  • Endometriosis / genetics*
  • Endometriosis / surgery
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genetic Testing
  • Genotype
  • Humans
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Repressor Proteins / genetics*
  • Uterine Diseases / diagnosis
  • Uterine Diseases / epidemiology*
  • Uterine Diseases / genetics*
  • Uterine Diseases / surgery
  • Young Adult

Substances

  • AHRR protein, human
  • Basic Helix-Loop-Helix Transcription Factors
  • Repressor Proteins