CTX-M-type beta-lactamase in Escherichia coli isolated from sick animals in Korea

Microb Drug Resist. 2009 Jun;15(2):139-42. doi: 10.1089/mdr.2009.0901.

Abstract

About 408 Escherichia coli were isolated from sick farm animals and pets during 2003-2006. Of these isolates, four strains showed resistance to third-generation cephalosporins. The bla(CTX-M-14) gene was encountered in three E. coli strains, each of which were isolated from two cows and a dog, respectively, and bla(CTX-M-15) was identified in an E. coli isolated from a pig. All bla(CTX-M) genes were found to be transferred. The pulsed-field gel electrophoresis pattern indicated that the CTX-M-type beta-lactamase-producing E. coli isolates were genetically diverse. This study shows the emergence of CTX-M-type beta-lactamase-producing E. coli in animals for the first time in Korea. Study results suggest the need for awareness and comprehensive monitoring of extended-spectrum beta-lactamases in animals because gene transfer can occur between animals as well as humans.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / pharmacology
  • Cattle / microbiology*
  • Cefotaxime / pharmacology
  • Ceftazidime / pharmacology
  • Conjugation, Genetic
  • DNA, Bacterial / analysis
  • DNA, Bacterial / genetics
  • Dogs / microbiology*
  • Drug Resistance, Multiple, Bacterial
  • Escherichia coli / drug effects
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / microbiology
  • Escherichia coli Infections / veterinary*
  • Korea
  • Microbial Sensitivity Tests
  • Swine / microbiology*
  • beta-Lactamases / genetics*

Substances

  • Anti-Bacterial Agents
  • DNA, Bacterial
  • Ceftazidime
  • beta-lactamase CTX-M-14
  • beta-lactamase CTX-M-15
  • beta-Lactamases
  • Cefotaxime