Isocoumarin glucosides from the scale insect fungus Torrubiella tenuis BCC 12732

J Nat Prod. 2009 Jul;72(7):1341-3. doi: 10.1021/np900082h.

Abstract

Three new isocoumarin glucosides (1, 3, and 4), 6,8-dihydroxy-3-methylisocoumarin (2), and 6,8-dihydroxy-3-hydroxymethylisocoumarin (5) were isolated from the scale insect pathogenic fungus Torrubiella tenuis BCC 12732. Structures of these compounds were elucidated using NMR spectroscopic and MS spectrometric analyses. Compound 5 exhibited moderate anti-HSV-1 and antimycobacterial activities with IC(50) and MIC values of 50 and 25 microg/mL, respectively.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antitubercular Agents / chemistry
  • Antitubercular Agents / isolation & purification*
  • Antitubercular Agents / pharmacology
  • Antiviral Agents / chemistry
  • Antiviral Agents / isolation & purification*
  • Antiviral Agents / pharmacology
  • Chlorocebus aethiops
  • Glucosides / chemistry
  • Glucosides / isolation & purification*
  • Glucosides / pharmacology
  • Herpesvirus 1, Human / drug effects
  • Humans
  • Hypocreales / chemistry*
  • Insecta / microbiology*
  • Isocoumarins / chemistry
  • Isocoumarins / isolation & purification*
  • Isocoumarins / pharmacology
  • Microbial Sensitivity Tests
  • Molecular Structure
  • Mycobacterium tuberculosis / drug effects
  • Plasmodium falciparum / drug effects

Substances

  • Antitubercular Agents
  • Antiviral Agents
  • Glucosides
  • Isocoumarins