Abstract
The decidua of the human maternal-fetal interface is a local source of intrauterine relaxin, and the choriodecidua expresses its receptor (LGR7). Since these tissues consist of a variety of cells, we sought to identify the primary cell(s) responsible for LGR7 expression and relaxin responsiveness.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Cell Line
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Cells, Cultured
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Cyclic AMP / metabolism
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Decidua / cytology*
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Decidua / drug effects*
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Dose-Response Relationship, Drug
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Enzyme-Linked Immunosorbent Assay
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Female
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Humans
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In Vitro Techniques
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Macrophages / drug effects
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Macrophages / metabolism
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Matrix Metalloproteinases / metabolism
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Polymerase Chain Reaction
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Pregnancy
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Pregnancy Outcome
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Receptors, G-Protein-Coupled / genetics
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Receptors, Peptide / genetics
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Relaxin / pharmacology*
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Stromal Cells / drug effects*
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Stromal Cells / metabolism*
Substances
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RXFP1 protein, human
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Receptors, G-Protein-Coupled
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Receptors, Peptide
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Relaxin
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Cyclic AMP
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Matrix Metalloproteinases