Comparative solution and solid-phase glycosylations toward a disaccharide library

Károly Agoston; Lars Kröger; Agnes Agoston; Gyula Dékány; Joachim Thiem

doi:10.1016/j.carres.2009.04.001

Comparative solution and solid-phase glycosylations toward a disaccharide library

Carbohydr Res. 2009 Aug 17;344(12):1428-33. doi: 10.1016/j.carres.2009.04.001. Epub 2009 Apr 10.

Authors

Károly Agoston¹, Lars Kröger, Agnes Agoston, Gyula Dékány, Joachim Thiem

Affiliation

¹ Department of Chemistry, Faculty of Science, University of Hamburg, Martin-Luther-King-Platz 6, D-20146 Hamburg, Germany. ka@glycom.dk

PMID: 19410240
DOI: 10.1016/j.carres.2009.04.001

Abstract

A comparative study on solution-phase and solid-phase oligosaccharide synthesis was performed. A 16-member library containing all regioisomers of Glc-Glc, Glc-Gal, Gal-Glc, and Gal-Gal disaccharides was synthesized both in solution and on solid phase. The various reaction conditions for different approaches and corresponding yields are analyzed and discussed.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Carbohydrate Sequence
Disaccharides / chemical synthesis*
Disaccharides / chemistry*
Glycosylation
Magnetic Resonance Spectroscopy
Molecular Sequence Data

Substances

Disaccharides