Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities

Adel Garas; John B Bremner; Jonathan Coates; John Deadman; Paul A Keller; Stephen G Pyne; David I Rhodes

doi:10.1016/j.bmcl.2009.04.046

Binaphthyl scaffolded peptoids via ring-closing metathesis reactions and their anti-bacterial activities

Bioorg Med Chem Lett. 2009 Jun 1;19(11):3010-3. doi: 10.1016/j.bmcl.2009.04.046. Epub 2009 Apr 18.

Authors

Adel Garas¹, John B Bremner, Jonathan Coates, John Deadman, Paul A Keller, Stephen G Pyne, David I Rhodes

Affiliation

¹ School of Chemistry, University of Wollongong, Wollongong, NSW, Australia.

PMID: 19409783
DOI: 10.1016/j.bmcl.2009.04.046

Abstract

An efficient synthesis of four new acyclic and four new cyclic binaphthyl-based cationic peptoids is described. These compounds had anti-bacterial activities with MIC values of 4-62 microg/mL against Staphylococcus aureus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology
Cations / chemistry
Naphthalenes / chemical synthesis
Naphthalenes / chemistry*
Peptoids / chemical synthesis*
Peptoids / chemistry
Peptoids / pharmacology
Staphylococcus aureus / drug effects
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Cations
Naphthalenes
Peptoids