[Factor VII deficiency revealed by intracranial hemorrhage]

L Sfaihi Ben Mansour; A Thabet; H Aloulou; H Turki; I Chabchoub; F Mhiri; Z Mnif; H Ben Ali; T Kammoun; M Hachicha

doi:10.1016/j.arcped.2009.03.009

[Factor VII deficiency revealed by intracranial hemorrhage]

Arch Pediatr. 2009 Jul;16(7):1024-7. doi: 10.1016/j.arcped.2009.03.009. Epub 2009 May 5.

[Article in French]

Authors

L Sfaihi Ben Mansour¹, A Thabet, H Aloulou, H Turki, I Chabchoub, F Mhiri, Z Mnif, H Ben Ali, T Kammoun, M Hachicha

Affiliation

¹ Service de pédiatrie, CHU Hédi Chaker, 3029 Sfax, Tunisie. lamia_benmansour@yahoo.fr

PMID: 19409767
DOI: 10.1016/j.arcped.2009.03.009

Abstract

Constitutional factor VII deficiency is a hereditary disease with recessive autosomic transmission. Its incidence is estimated to be 1/1,000,000 in the general population. We report a case of severe factor VII deficiency in infancy revealed by an intracranial hemorrhage in a 2-month-old infant. We describe the clinical, biological and therapeutic characteristics of this disease.

Publication types

Case Reports

MeSH terms

Agenesis of Corpus Callosum
Antigens / therapeutic use
Cerebral Ventricles / pathology
Chromosome Aberrations
Combined Modality Therapy
Consanguinity
Corpus Callosum / pathology
Echoencephalography
Factor VII / therapeutic use
Factor VII Deficiency / diagnosis*
Factor VII Deficiency / genetics
Genes, Recessive
Genetic Carrier Screening
Humans
Infant
Intracranial Hemorrhages / etiology*
Intracranial Hemorrhages / genetics
Intracranial Hemorrhages / surgery
Male
Occipital Lobe / pathology
Recombinant Proteins / therapeutic use
Recurrence
Tomography, X-Ray Computed
Ventriculoperitoneal Shunt

Substances

Antigens
Recombinant Proteins
factor VII clotting antigen
Factor VII