Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates

Yuxiu Liu; Shaohua Liu; Yonghong Li; Haibin Song; Qingmin Wang

doi:10.1016/j.bmcl.2009.04.048

Synthesis and biological evaluation of arylhydrazinocyanoacrylates and N-aryl pyrazolecarboxylates

Bioorg Med Chem Lett. 2009 Jun 1;19(11):2953-6. doi: 10.1016/j.bmcl.2009.04.048. Epub 2009 Apr 18.

Authors

Yuxiu Liu¹, Shaohua Liu, Yonghong Li, Haibin Song, Qingmin Wang

Affiliation

¹ State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, China.

PMID: 19406637
DOI: 10.1016/j.bmcl.2009.04.048

Abstract

A series of arylhydrazino-substituted cyanoacrylates 3 and N-aryl pyrazolecarboxylates 6 were synthesized and their bioactivities were evaluated. Though compounds 3 were designed as herbicide, some of them showed fungicidal activity and anti-tumor activity. Some of the compounds 6 exhibited plant growth regulatory activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Antineoplastic Agents / pharmacology
Cell Line, Tumor
Crystallography, X-Ray
Cyanoacrylates / chemical synthesis
Cyanoacrylates / chemistry*
Cyanoacrylates / pharmacology
Herbicides / chemical synthesis*
Herbicides / chemistry
Herbicides / pharmacology
Humans
Pyrazoles / chemical synthesis
Pyrazoles / chemistry*
Pyrazoles / pharmacology

Substances

Antifungal Agents
Antineoplastic Agents
Cyanoacrylates
Herbicides
Pyrazoles