Relative contribution of VKORC1, CYP2C9, and INR response to warfarin stable dose

Blood. 2009 Apr 23;113(17):4125-6. doi: 10.1182/blood-2009-01-200600.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Aryl Hydrocarbon Hydroxylases / genetics*
  • Aryl Hydrocarbon Hydroxylases / metabolism
  • Cytochrome P-450 CYP2C9
  • Dose-Response Relationship, Drug
  • Genotype
  • Humans
  • International Normalized Ratio
  • Mixed Function Oxygenases / genetics*
  • Mixed Function Oxygenases / metabolism
  • Substrate Specificity
  • Vitamin K Epoxide Reductases
  • Warfarin / pharmacology*

Substances

  • Warfarin
  • Mixed Function Oxygenases
  • CYP2C9 protein, human
  • Cytochrome P-450 CYP2C9
  • Aryl Hydrocarbon Hydroxylases
  • VKORC1 protein, human
  • Vitamin K Epoxide Reductases