There seems to be a cluster of potentially atherogenic and diabetogenic abnormalities in subjects with central adiposity (high waist to hip ratio) and insulin resistance. To test whether reversing insulin resistance could lead to decreased vascular and diabetic risks, a trial using a drug to complement life-style modification measures is necessary. BIGPRO trial proposes to examine the efficacy of metformin, along with diet and exercise advice, in reducing over one year the metabolic abnormalities encountered in non-diabetic subjects with central adiposity. BIGPRO is designed as a randomized double blind one-year trial of metformin (2 tabs/d, i.e. 1,700 mg/d) versus matching placebo (2 tabs/d). Men aged 40-55 years, with a waist to hip ratio greater than or equal to 0.95 and women aged 45-65 years with a waist to hip ratio greater than or equal to 0.80, are eligible to enter the trial, unless they have diabetes, cardiovascular disease, kidney dysfunction, serious illness, or are receiving extensive medical treatment. Between the two treatment groups the changes in the following endpoints will be compared after one year study: waist to hip ratio, blood pressure, blood lipids, glucose, insulin, fibrinolytic activity. At least 400 subjects are expected to complete the trial. The recruitment and follow-up will be distributed among 33 medical centers from various University Hospitals in France. If metformin proves to be effective in reducing the metabolic abnormalities associated with insulin resistance, it may be a possible candidate for a long term trial for primary prevention of cardiovascular accidents and diabetes.