HLA-DRB115 and cerebrospinal-fluid-specific oligoclonal immunoglobulin G bands lower age at attainment of important disease milestones in multiple sclerosis

J Neuroimmunol. 2009 May 29;210(1-2):128-30. doi: 10.1016/j.jneuroim.2009.03.005. Epub 2009 Mar 26.

Abstract

Carriage of HLA-DRB1*15 is the most important genetic risk factor in multiple sclerosis (MS), while CSF-specific oligoclonal immunoglobulin G bands (OCB) constitute the most sensitive biochemical marker for diagnosing MS. We demonstrated in an earlier study the interdependence of HLA-DRB1 genotype and OCB status; the effect of these phenotypic features on MS prognosis remains controversial, however. We investigated by survival analysis the impact of each variable on age at two important MS milestones: onset of clinical symptoms and an Expanded Disability Status Scale (EDSS) score of 6.0. Both carriage of HLA-DRB1*15 and the presence of OCB hastened attainment of EDSS 6.0.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Age Factors
  • Age of Onset
  • Biomarkers / analysis
  • Biomarkers / cerebrospinal fluid
  • DNA Mutational Analysis
  • Disability Evaluation
  • Disease Progression
  • Female
  • Genetic Markers / genetics
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • HLA-DR Antigens / genetics*
  • HLA-DRB1 Chains
  • Heterozygote
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / cerebrospinal fluid*
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / mortality
  • Oligoclonal Bands / analysis
  • Oligoclonal Bands / cerebrospinal fluid*
  • Predictive Value of Tests
  • Prognosis
  • Survival Analysis

Substances

  • Biomarkers
  • Genetic Markers
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • HLA-DRB1*15 antigen
  • Oligoclonal Bands