Analysis of dynamic morphogen scale invariance

J R Soc Interface. 2009 Dec 6;6(41):1179-91. doi: 10.1098/rsif.2009.0015. Epub 2009 Mar 11.

Abstract

During the development of some tissues, fields of multipotent cells differentiate into distinct cell types in response to the local concentration of a signalling factor called a morphogen. Typically, individual organisms within a population differ in size, but their body plans appear to be scaled versions of a common template. Similarly, closely related species may differ by three or more orders of magnitude in size, yet common structures between species scale to have similar proportions. In standard reaction-diffusion equations, the morphogen range has a length scale that depends on a balance between kinetic and transport processes and not on the length or size of the field of cells being patterned. However, as shown here for a class of morphogen-patterning systems, a number of conditions lead to scale invariance of the morphogen distribution at equilibrium and during the transient approach to equilibrium. Equilibrium scale invariance requires conservation of the total binding site number and total input flux. Dynamic scale invariance additionally requires sufficient binding to slow the diffusion of ligand. The equations derived herein can be extended to the study of other perturbations to gain further insight into the processes regulating the robustness and scaling of morphogen-mediated pattern formation.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Algorithms
  • Animals
  • Binding Sites
  • Biological Transport
  • Cell Communication
  • Cell Differentiation*
  • Diffusion
  • Drosophila / physiology
  • Kinetics
  • Ligands
  • Models, Biological
  • Models, Statistical
  • Models, Theoretical
  • Morphogenesis*
  • Time Factors

Substances

  • Ligands