Finished TATB (1,3,5-triamino-2,4,6-trinitrobenzene) explosive safety under 800W microwave irradiation was experimented. No burning, deflagration and detonation were observed during 30-min continuous irradiation and no remarkable change were observed after irradiation according to HPLC, particles size analysis, and differential thermal analysis. Wet TATB sampled from synthesis line was irradiated with microwave vacuum method and irradiated TATB was measured to accord with military standard specifications including appearance, moisture and volatile, chloride content, HPLC, mean particle size, DTA exothermic peak, ash, acetone soluble content, PH value, etc. Microwave vacuum desiccation was deemed laborsaving, energy-efficient, and practicable compared to conventional processing method.