Thyroid disruption by low-dose BDE-47 in prenatally exposed lambs

Neonatology. 2009;96(2):120-4. doi: 10.1159/000209316. Epub 2009 Mar 24.

Abstract

The purpose of this study was to evaluate whether polybrominated diphenyl ethers (PBDE) at levels reported for human populations affect the thyroid state in pregnant sheep and lambs. Pregnant sheep were exposed to vehicle or BDE-47 (0.2, 2 and 20 microg/kg b.w.) from the 5th to 15th week of gestation by intravenous injections weekly. Thyroid hormone levels and BDE-47 content in the blood of sheep and lambs and adipose tissue were analyzed. We observed a significant decrease in total T(4) and T(3) in exposed lambs without any effect in pregnant sheep. Our finding indicates that prenatal low-dose PBDE exposure results in PBDE storage in fat of offspring and can affect thyroid metabolism in the developing fetus.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adipose Tissue / drug effects
  • Adipose Tissue / metabolism
  • Animals
  • Animals, Newborn / metabolism
  • Embryo, Mammalian / drug effects*
  • Embryo, Mammalian / embryology
  • Embryo, Mammalian / metabolism
  • Environmental Pollutants / metabolism
  • Environmental Pollutants / toxicity*
  • Female
  • Gestational Age
  • Halogenated Diphenyl Ethers
  • Maternal Exposure / adverse effects*
  • Polybrominated Biphenyls / metabolism
  • Polybrominated Biphenyls / toxicity*
  • Pregnancy
  • Sheep
  • Thyroid Gland / drug effects*
  • Thyroid Gland / embryology
  • Thyroid Gland / metabolism
  • Thyroxine / metabolism
  • Triiodothyronine / metabolism

Substances

  • Environmental Pollutants
  • Halogenated Diphenyl Ethers
  • Polybrominated Biphenyls
  • Triiodothyronine
  • 2,2',4,4'-tetrabromodiphenyl ether
  • Thyroxine