Building molecular complexity via tandem Ru-catalyzed isomerization/C-H activation

Org Lett. 2009 Apr 16;11(8):1749-52. doi: 10.1021/ol900243x.

Abstract

A tandem isomerization/C-H activation of allylic alcohols was performed using a catalytic amount of RuCl(2)(PPh(3))(3). A variety of ortho alkylated ketones have been obtained in excellent yields. This tandem process relies on an in situ generation of a carbonyl functional group that directs the ortho C-H bond activation.