2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation

Jimmy J Weterings; Selina Khan; Gerbrand J van der Heden van Noort; Cornelis J M Melief; Herman S Overkleeft; Sjoerd H van der Burg; Ferry Ossendorp; Gijsbert A van der Marel; Dmitri V Filippov

doi:10.1016/j.bmcl.2009.02.095

2-Azidoalkoxy-7-hydro-8-oxoadenine derivatives as TLR7 agonists inducing dendritic cell maturation

Bioorg Med Chem Lett. 2009 Apr 15;19(8):2249-51. doi: 10.1016/j.bmcl.2009.02.095. Epub 2009 Feb 27.

Authors

Jimmy J Weterings¹, Selina Khan, Gerbrand J van der Heden van Noort, Cornelis J M Melief, Herman S Overkleeft, Sjoerd H van der Burg, Ferry Ossendorp, Gijsbert A van der Marel, Dmitri V Filippov

Affiliation

¹ Leiden Institute of Chemistry, Leiden University, Leiden, The Netherlands.

PMID: 19299126
DOI: 10.1016/j.bmcl.2009.02.095

Abstract

The synthesis of an array of 2-azidoalkoxy substituted 7-hydro-8-oxoadenines is described. The relation of the structure of these compounds and their ability to induce maturation of dendritic cells is evaluated.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Adenine / analogs & derivatives*
Adenine / chemical synthesis
Adenine / pharmacology
Amines / chemistry
Animals
Azides / chemistry
Cell Differentiation / drug effects*
Cell Differentiation / physiology
Dendritic Cells / cytology*
Dendritic Cells / drug effects*
Dendritic Cells / physiology
Mice
Toll-Like Receptor 7 / agonists*
Toll-Like Receptor 7 / physiology

Substances

Amines
Azides
Toll-Like Receptor 7
8-hydroxyadenine
Adenine