Gold nanorod/Fe3O4 nanoparticle "nano-pearl-necklaces" for simultaneous targeting, dual-mode imaging, and photothermal ablation of cancer cells

Angew Chem Int Ed Engl. 2009;48(15):2759-63. doi: 10.1002/anie.200805282.

Abstract

Gold and pearls: Multifunctional nanoparticles, each composed of a single, amine-modified gold nanorod, decorated with multiple "pearls" of Fe(3)O(4) nanoparticles capped with carboxy groups, are prepared. Their effectiveness in simultaneous targeting, dual-mode imaging, and photothermal ablation of breast cancer cells is demonstrated.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibodies, Monoclonal / chemistry
  • Antibodies, Monoclonal, Humanized
  • Cell Line, Tumor
  • Contrast Media / chemistry*
  • Ferrosoferric Oxide / chemistry*
  • Gold / chemistry*
  • Humans
  • Magnetic Resonance Imaging
  • Metal Nanoparticles / analysis
  • Metal Nanoparticles / chemistry*
  • Metal Nanoparticles / ultrastructure
  • Microscopy, Electron, Transmission
  • Microscopy, Fluorescence
  • Nanotubes / chemistry*
  • Nanotubes / ultrastructure
  • Neoplasms / therapy*
  • Photochemistry
  • Scattering, Radiation
  • Trastuzumab

Substances

  • Antibodies, Monoclonal
  • Antibodies, Monoclonal, Humanized
  • Contrast Media
  • Gold
  • Trastuzumab
  • Ferrosoferric Oxide