Depression and psychiatric symptoms preceding onset of dementia in a family with early-onset Alzheimer disease with a novel PSEN1 mutation

J Neurol. 2009 Aug;256(8):1351-3. doi: 10.1007/s00415-009-5096-4. Epub 2009 Mar 12.
No abstract available

Publication types

  • Case Reports
  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alzheimer Disease / complications*
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / pathology
  • Atrophy / etiology
  • Atrophy / pathology
  • Brain / diagnostic imaging
  • Brain / pathology
  • Brain / physiopathology
  • Cognition Disorders / genetics
  • Cognition Disorders / pathology
  • Cognition Disorders / physiopathology
  • DNA Mutational Analysis
  • Depressive Disorder / genetics*
  • Depressive Disorder / pathology
  • Depressive Disorder / physiopathology
  • Disease Progression
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genetic Testing
  • Genotype
  • Hallucinations / pathology
  • Hallucinations / physiopathology
  • Humans
  • Inheritance Patterns / genetics
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neurocognitive Disorders / genetics*
  • Neurocognitive Disorders / pathology
  • Neurocognitive Disorders / physiopathology
  • Parkinsonian Disorders / genetics
  • Parkinsonian Disorders / pathology
  • Parkinsonian Disorders / physiopathology
  • Pedigree
  • Presenilin-1 / genetics*
  • Tomography, Emission-Computed, Single-Photon

Substances

  • PSEN1 protein, human
  • Presenilin-1