Evaluation of antibodies against different Epstein-Barr virus nuclear antigen 1 peptides in diagnosis of nasopharyngeal carcinoma

Clin Vaccine Immunol. 2009 Apr;16(4):592-3. doi: 10.1128/CVI.00207-08. Epub 2009 Mar 11.

Abstract

Epstein-Barr virus nuclear antigen 1 (EBNA1) is a protein expressed consistently in nasopharyngeal carcinoma (NPC). Although antibody levels against three different EBNA1 peptides were all high in NPC patients, the correlation between any two biomarkers was low. Therefore, the selection of distinct EBNA1 peptides could render different results in serological detection for individuals with NPC.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Viral / blood*
  • Epstein-Barr Virus Nuclear Antigens*
  • Female
  • Herpesvirus 4, Human / immunology
  • Humans
  • Male
  • Middle Aged
  • Nasopharyngeal Neoplasms / diagnosis*
  • Nasopharyngeal Neoplasms / virology
  • Peptides*
  • Sensitivity and Specificity
  • Young Adult

Substances

  • Antibodies, Viral
  • Epstein-Barr Virus Nuclear Antigens
  • Peptides
  • EBV-encoded nuclear antigen 1