The (mis) use of bone resorption markers in the context of bisphosphonate exposure, dental surgery and osteonecrosis of the jaw

Clin Biochem. 2009 Jul;42(10-11):1194-6. doi: 10.1016/j.clinbiochem.2009.02.014. Epub 2009 Mar 2.

Abstract

Objectives: To evaluate the argument for use of bone resorption markers in patients exposed to bisphosphonates and requiring dental surgery to prevent development of osteonecrosis of the jaw.

Methods: Review of literature.

Results: 5 primary reports and a number of reviews were considered.

Conclusions: There is insufficient evidence to recommend use of bone resorption markers in patients exposed to bisphosphonates prior to dental surgery as a routine test to assess risk of osteonecrosis of the jaw.

Publication types

  • Meta-Analysis

MeSH terms

  • Biomarkers / metabolism
  • Bone Resorption / metabolism*
  • Diphosphonates / therapeutic use*
  • Humans
  • Jaw Diseases / pathology*
  • Oral Surgical Procedures*
  • Osteonecrosis / pathology*

Substances

  • Biomarkers
  • Diphosphonates