Nosocomial spread of linezolid-resistant Staphylococcus haemolyticus infections in an intensive care unit

Diagn Microbiol Infect Dis. 2009 Apr;63(4):398-402. doi: 10.1016/j.diagmicrobio.2008.12.008. Epub 2009 Feb 18.

Abstract

This report documents the nosocomial spread for an 18-month period of a single clone of linezolid- and teicoplanin-resistant Staphylococcus haemolyticus associated primarily with catheter-related bacteremia in intensive care unit patients. All linezolid-resistant isolates had the same G2576T mutation in at least 1 copy of the 23S rRNA gene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology*
  • Adult
  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Bacteremia / epidemiology
  • Bacteremia / microbiology
  • Catheterization / adverse effects
  • Cluster Analysis
  • Cross Infection / epidemiology*
  • Cross Infection / microbiology
  • Drug Resistance, Bacterial*
  • Electrophoresis, Gel, Pulsed-Field
  • Female
  • Humans
  • Intensive Care Units
  • Linezolid
  • Male
  • Microbial Sensitivity Tests
  • Middle Aged
  • Oxazolidinones / pharmacology*
  • Point Mutation
  • RNA, Ribosomal, 23S / genetics
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / microbiology
  • Staphylococcus haemolyticus / drug effects*
  • Staphylococcus haemolyticus / isolation & purification*
  • Teicoplanin / pharmacology

Substances

  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • RNA, Ribosomal, 23S
  • Teicoplanin
  • Linezolid