Delayed optic nerve complications after proton beam irradiation

Ann Ophthalmol (Skokie). 2008 Fall-Winter;40(3-4):166-70.

Abstract

We present two cases of delayed optic nerve complications following proton beam radiotherapy. Patient 1 received radiotherapy after surgery for clival chordoma and developed sequential radiation optic neuropathy at 5 and 9 months. Patient 2 developed optic nerve hemorrhage post radiotherapy for optic nerve sheath meningioma. These two cases of blindness demonstrate the risks associated with proton beam radiotherapy.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Chordoma / radiotherapy
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Meningeal Neoplasms / radiotherapy
  • Meningioma / radiotherapy
  • Middle Aged
  • Optic Nerve / pathology
  • Optic Nerve / radiation effects*
  • Optic Nerve Diseases / diagnosis
  • Optic Nerve Diseases / etiology*
  • Protons
  • Radiation Injuries / diagnosis
  • Radiation Injuries / etiology*
  • Skull Base Neoplasms / radiotherapy
  • Visual Acuity

Substances

  • Protons