Sulfated steroids: ptilosteroids A-C and ptilosaponosides A and B from the Solomon Islands marine sponge Ptilocaulis spiculifer

J Nat Prod. 2009 Apr;72(4):760-3. doi: 10.1021/np800758c.

Abstract

Three new pregnanes, ptilosteroid A (1), ptilosteroid B (2), and ptilosteroid C (3), and two new pregnane glycosides, ptilosaponoside A (4) and ptilosaponoside B (5), were isolated from the marine sponge Ptilocaulis spiculifer collected in the Solomon Islands. The structures were determined by spectroscopic methods. Biological tests of these compounds showed that they are not cytotoxic against KB cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drug Screening Assays, Antitumor
  • Glycosides / chemistry
  • Glycosides / isolation & purification*
  • Glycosides / pharmacology
  • Humans
  • KB Cells
  • Marine Biology
  • Melanesia
  • Molecular Structure
  • Nuclear Magnetic Resonance, Biomolecular
  • Porifera / chemistry*
  • Pregnanes / chemistry
  • Pregnanes / isolation & purification*
  • Pregnanes / pharmacology
  • Saponins / chemistry
  • Saponins / isolation & purification*
  • Saponins / pharmacology
  • Sulfuric Acid Esters / chemistry
  • Sulfuric Acid Esters / isolation & purification*
  • Sulfuric Acid Esters / pharmacology

Substances

  • Glycosides
  • Pregnanes
  • Saponins
  • Sulfuric Acid Esters
  • ptilosaponoside A
  • ptilosaponoside B
  • ptilosteroid A
  • ptilosteroid B
  • ptilosteroid C