A photostable fluorescent probe for targeted imaging of tumour cells possessing integrin alpha(v)beta(3)

Mol Biosyst. 2009 Mar;5(3):241-3. doi: 10.1039/b820576k. Epub 2009 Jan 7.

Abstract

A one-step S(N)Ar(H) reaction has been used for the synthesis of photostable probe , which has good water solubility and low cytotoxicity; this probe can be used for targeted imaging of tumour cells by virtue of specific binding between integrin alpha(v)beta(3) and an arginine-glycine-aspartic acid tripeptide sequence.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridine Orange
  • Cell Line, Tumor
  • Cell Proliferation
  • Cell Survival
  • Flow Cytometry
  • Fluorescent Dyes / metabolism*
  • Humans
  • Imaging, Three-Dimensional / methods*
  • Integrin alphaVbeta3 / metabolism*
  • Light*
  • Microscopy, Confocal
  • Neoplasms / metabolism*
  • Photobleaching
  • Spectrophotometry, Ultraviolet

Substances

  • Fluorescent Dyes
  • Integrin alphaVbeta3
  • Acridine Orange