Abstract
Zinc benefits: The first catalytic asymmetric phospha-Michael addition of enones has been developed. Under mild reaction conditions, the gamma-oxo phosphonates could be obtained in high yields (up to 99%) with excellent enantioselectivities (93-99% ee; see scheme). The strategy makes the asymmetric synthesis of biologically important phosphonate compounds more accessible.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Catalysis
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Combinatorial Chemistry Techniques
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Ketones / chemical synthesis*
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Ketones / chemistry
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Molecular Structure
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Organophosphonates / chemical synthesis*
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Organophosphonates / chemistry
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Phosphites / chemistry*
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Phosphorylation
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Stereoisomerism
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Zinc / chemistry*
Substances
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Ketones
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Organophosphonates
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Phosphites
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Zinc