Adult-onset Still's disease: hepatic involvement and various serum markers relating to the disease activity

Jpn J Med. 1991 May-Jun;30(3):247-50. doi: 10.2169/internalmedicine1962.30.247.

Abstract

A 53-year-old woman was admitted to our hospital due to high fever, arthralgia and skin rash. Main laboratory data included the following: WBC 17,100/mm, GOT 58 U, GPT 47 U, LDH 1,510 U, ferritin 19,000 ng/ml, adenosine deaminase 79.1 U/l. She was diagnosed as having adult-onset Still's disease. Aspirin (3.0 g/day) and prednisolone (40 mg/day) were administered. All the symptoms and laboratory data improved rapidly. Adenosine deaminase, ferritin, and LDH are considered to originate mainly from the liver. Liver injury in this disease may be a primary lesion, and various serum markers may be associated with the liver abnormalities.

Publication types

  • Case Reports

MeSH terms

  • Adenosine Deaminase / blood*
  • Aspirin / therapeutic use
  • Biomarkers
  • Clinical Enzyme Tests*
  • Diagnosis, Differential
  • Erythema / diagnosis
  • Erythema / etiology
  • Female
  • Ferritins / analysis*
  • Fever / diagnosis*
  • Humans
  • Infections / diagnosis
  • Isoenzymes
  • L-Lactate Dehydrogenase / blood*
  • Liver / enzymology
  • Liver / pathology
  • Middle Aged
  • Neoplasms / diagnosis
  • Prednisolone / therapeutic use
  • Skin / pathology
  • Still's Disease, Adult-Onset / blood
  • Still's Disease, Adult-Onset / diagnosis*
  • Still's Disease, Adult-Onset / drug therapy
  • Still's Disease, Adult-Onset / pathology

Substances

  • Biomarkers
  • Isoenzymes
  • Ferritins
  • Prednisolone
  • L-Lactate Dehydrogenase
  • Adenosine Deaminase
  • Aspirin