Testing protocols: care of biological samples in a rural setting

Clin Nurs Res. 2009 Feb;18(1):6-22. doi: 10.1177/1054773808327551.

Abstract

The purpose of this study is to evaluate collection, transport, and storage protocols of urine and air allergen samples from infants in a rural setting. Infant urine and aeroallergen samples (n = 21) are collected in the home setting in rural areas where time and distance to the central laboratory is a consideration. Urine samples are analyzed using ELISA tests after being transported using three different techniques: (a) ambient temperature, (b) dry ice, and (c) packaged on dry ice and shipped commercially. Following initial ELISA testing for levels of cytokines, urine samples are frozen at -70 degrees Celsius for 6 months. Samples are then reanalyzed for levels of cytokines. Dust samples are analyzed for levels of aeroallergens, stored at 4 degrees for 6 months, and reanalyzed. The integrity of samples varies by biomarker, shipment temperature, and storage time, creating a high degree of variability in results.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Allergens / analysis
  • Asthma / etiology
  • Asthma / prevention & control
  • Biomarkers / analysis
  • Clinical Protocols*
  • Enzyme-Linked Immunosorbent Assay
  • Humans
  • Infant
  • Nebraska
  • Rural Population
  • Specimen Handling / standards*
  • Urinalysis
  • Wyoming

Substances

  • Allergens
  • Biomarkers