Selected nutritional and immunological indices of 118 patients with methicillin-resistant Staphylococcus aureus (MRSA) were reviewed retrospectively. Those patients with nosocomial infections had significantly (P less than .05) lower levels of serum albumin, total protein, absolute lymphocyte, and percentage of lymphocytes (on differential) than all others (ie, community-acquired infections and colonizations and nosocomial colonizations). Therefore, these parameters might be important indicators of subsequent MRSA infestation in certain patient populations.