An emissive C analog distinguishes between G, 8-oxoG, and T

Org Lett. 2009 Mar 5;11(5):1115-8. doi: 10.1021/ol802656n.

Abstract

A minimally disruptive fluorescent dC analog provides a rapid and non-destructive method for in vitro detection of G, 8-oxoG, and T, the downstream transverse mutation product.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • DNA Damage
  • Fluorescent Dyes / chemical synthesis*
  • Fluorescent Dyes / chemistry
  • Guanine / analogs & derivatives*
  • Guanine / analysis
  • Guanine / chemistry
  • Molecular Structure
  • Mutation
  • Oxidation-Reduction
  • Oxidative Stress

Substances

  • Fluorescent Dyes
  • 8-hydroxyguanine
  • Guanine