blaCTX-M genes in escherichia coli strains from Croatian Hospitals are located in new (blaCTX-M-3a) and widely spread (blaCTX-M-3a and blaCTX-M-15) genetic structures

Antimicrob Agents Chemother. 2009 Apr;53(4):1630-5. doi: 10.1128/AAC.01431-08. Epub 2009 Feb 2.

Abstract

CTX-M-producing Escherichia coli isolates from three Croatian hospitals were analyzed. All bla(CTX-M-15) genes and one bla(CTX-M-3a) gene resided in widely spread ISEcp1 transposition modules, but other bla(CTX-M-3a) genes were in a new configuration with two IS26 copies, indicating a new event of gene mobilization from a Kluyvera ascorbata genome. The study confirmed the role of the E. coli ST131 clonal group with IncFII-type plasmids in the spread of bla(CTX-M-15) and of IncL/M pCTX-M3-type plasmids in the dissemination of bla(CTX-M-3a).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • DNA Transposable Elements
  • Escherichia coli / drug effects
  • Escherichia coli / enzymology
  • Escherichia coli / genetics*
  • Molecular Sequence Data
  • Plasmids
  • Polymerase Chain Reaction
  • beta-Lactamases / genetics*

Substances

  • DNA Transposable Elements
  • beta-lactamase CTX-M-15
  • beta-lactamase CTX-M-3
  • beta-Lactamases

Associated data

  • GENBANK/FM213371