The stem of cancer

Cancer Cell. 2009 Feb 3;15(2):87-9. doi: 10.1016/j.ccr.2009.01.011.

Abstract

Despite great advances in our understanding of tumor initiation and progression, the identity of the "cell of origin" of cancer remains elusive. Two recent publications provide experimental evidence that normal intestinal stem cells are the cells of origin of intestinal cancer in the mouse.

Publication types

  • Comment

MeSH terms

  • Animals
  • Biomarkers, Tumor / metabolism
  • Humans
  • Intestinal Mucosa / cytology*
  • Intestinal Mucosa / physiology
  • Mice
  • Neoplasms* / pathology
  • Neoplasms* / physiopathology
  • Neoplastic Stem Cells / physiology*
  • Receptors, G-Protein-Coupled / genetics
  • Receptors, G-Protein-Coupled / metabolism
  • Stem Cells / physiology*

Substances

  • Biomarkers, Tumor
  • Lgr5 protein, mouse
  • Receptors, G-Protein-Coupled