Highly stable indomethacin glasses resist uptake of water vapor

J Phys Chem B. 2009 Feb 26;113(8):2422-7. doi: 10.1021/jp808838t.

Abstract

Mass uptake of water vapor was measured as a function of relative humidity for indomethacin glasses prepared using physical vapor deposition at different substrate temperatures. Highly stable glasses were produced on substrates at 265 K (0.84Tg) by depositing at 0.2 nm/s while samples similar to melt-cooled glasses were produced at 315 K and 5 nm/s. Samples deposited at 315 K absorb approximately the same amount of water as glasses prepared by supercooling the melt while stable glasses absorb a factor of 5 less water. Unexpectedly, the diffusion of water in the stable glass samples is 5-10 times faster than in the glass prepared by cooling the liquid.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Diffusion
  • Glass / chemistry*
  • Indomethacin / chemistry*
  • Temperature
  • Water / chemistry*

Substances

  • Water
  • Indomethacin