Abstract
As part of a bioprospecting program aimed at the discovery of potential anticancer drugs, two new guanidine-type alkaloids, nitensidines D and E (1, 2), and the known pterogynine (3), pterogynidine (4), and galegine (5), were isolated from the leaves of Pterogyne nitens. The structures of 1 and 2 were established on the basis of spectroscopic data interpretation. These compounds were tested against a small panel of human cancer cell lines. Compound 2 exhibited cytotoxicity for HL-60 (human myeloblastic leukemia) and SF-245 (human glioblastoma) cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology*
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology*
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Brazil
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Drug Screening Assays, Antitumor
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Fabaceae / chemistry*
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Guanidines / chemistry
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Guanidines / isolation & purification*
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Guanidines / pharmacology*
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HL-60 Cells
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Humans
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Molecular Structure
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Plant Leaves / chemistry
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Guanidines
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nitensidine D
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nitensidine E