[Tuberculosis-associated immune reconstitution inflammatory syndrome]

Infez Med. 2008 Dec;16(4):193-9.
[Article in Italian]

Abstract

The prognosis of HIV-infected patients has dramatically improved since the advent of HAART. The immune recovery associated with HAART may result in immuno-pathological reactions and clinical deterioration when HAART is initiated in patients with tuberculosis (TB). This phenomenon is defined as immune reconstitution inflammatory syndrome (IRIS). In this review, we summarise the epidemiology, clinical presentations and management of TB-associated IRIS.

Publication types

  • English Abstract
  • Review

MeSH terms

  • AIDS-Related Opportunistic Infections / diagnosis
  • AIDS-Related Opportunistic Infections / drug therapy
  • AIDS-Related Opportunistic Infections / epidemiology
  • AIDS-Related Opportunistic Infections / immunology*
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Antitubercular Agents / therapeutic use
  • Drug Therapy, Combination
  • Evidence-Based Medicine
  • Glucocorticoids / therapeutic use
  • Humans
  • Immune Reconstitution Inflammatory Syndrome / chemically induced
  • Immune Reconstitution Inflammatory Syndrome / diagnosis
  • Immune Reconstitution Inflammatory Syndrome / etiology*
  • Immune Reconstitution Inflammatory Syndrome / immunology
  • Immune Reconstitution Inflammatory Syndrome / microbiology
  • Incidence
  • Prevalence
  • Risk Factors
  • Rome / epidemiology
  • Treatment Outcome
  • Tuberculosis, Pulmonary / diagnosis
  • Tuberculosis, Pulmonary / drug therapy
  • Tuberculosis, Pulmonary / epidemiology
  • Tuberculosis, Pulmonary / immunology*

Substances

  • Antitubercular Agents
  • Glucocorticoids