Strontium oxide doped quaternary glasses: effect on structure, degradation and cytocompatibility

J Mater Sci Mater Med. 2009 Jun;20(6):1339-46. doi: 10.1007/s10856-008-3688-7. Epub 2009 Jan 10.

Abstract

This preliminary study focuses on the effect of adding SrO to a Ti-containing quaternary phosphate glass system denoted by P(2)O(5)-Na(2)O-CaO-TiO(2). The following four different glass compositions were manufactured: 0.5P(2)O(5)-0.17Na(2)O-0.03TiO(2)-(0.3-x)CaO-xSrO where x = 0, 0.01, 0.03 and 0.05. Structural characterisation revealed glass transition temperatures in the range 427-437 degrees C and the presence of sodium calcium phosphate as the dominant phase in all the glasses. Degradation and ion release studies conducted over a 15-day period revealed that the Sr-containing glasses showed significantly higher degradation and ion release rates than the Sr-free glass. Cytocompatibility studies performed over a 7-day period using MG63 cells showed that the addition of 5 mol% SrO yielded glasses with cell viability nearly equivalent to that observed for quaternary TiO(2) glasses.

MeSH terms

  • Biocompatible Materials / chemistry*
  • Biodegradation, Environmental
  • Cell Line
  • Cell Proliferation
  • Cell Survival
  • Crystallization
  • Glass / chemistry*
  • Humans
  • Hydrogen-Ion Concentration
  • Indicators and Reagents / metabolism
  • Ions / metabolism
  • Microscopy, Electron, Scanning
  • Osteoblasts / cytology
  • Osteoblasts / metabolism
  • Osteoblasts / physiology
  • Osteoblasts / ultrastructure
  • Oxazines / metabolism
  • Oxides / chemistry*
  • Phase Transition
  • Strontium / chemistry*
  • Temperature
  • X-Ray Diffraction
  • Xanthenes / metabolism

Substances

  • Biocompatible Materials
  • Indicators and Reagents
  • Ions
  • Oxazines
  • Oxides
  • Xanthenes
  • resazurin
  • Strontium