Abstract
We present a novel process for the production of three-layer Composite Nanoparticles (CNPs) in the size range 100-300 nm with an up-converting phosphor interior, a coating of porphyrin photosensitizer, and a biocompatible PEG outer layer to prevent clearance by the reticuloendothelial system. We show that these CNPs produce millimolar amounts of singlet oxygen at NIR intensities far less than other two-photon techniques.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biocompatible Materials
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Humans
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Light
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Metals, Rare Earth / radiation effects
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Mononuclear Phagocyte System / physiology*
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Mononuclear Phagocyte System / radiation effects
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Nanoparticles*
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Nanotechnology / methods
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Particle Size
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Photochemotherapy / instrumentation*
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Photochemotherapy / methods*
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Photons
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Photosensitizing Agents
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Polyethylene Glycols
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Porphyrins
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Singlet Oxygen / analysis
Substances
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Biocompatible Materials
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Metals, Rare Earth
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Photosensitizing Agents
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Porphyrins
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Singlet Oxygen
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Polyethylene Glycols