Alternative splicing: regulation without regulators

Nat Struct Mol Biol. 2009 Jan;16(1):13-5. doi: 10.1038/nsmb0109-13.

Abstract

Alternative splicing is typically thought to be controlled by RNA binding proteins that modulate the activity of the spliceosome. A new study not only demonstrates that alternative splicing can be regulated without the involvement of auxiliary splicing factors, but also provides mechanistic insight into how this can occur.

Publication types

  • News

MeSH terms

  • Alternative Splicing*
  • Enhancer Elements, Genetic / genetics
  • Exons
  • Gene Expression Regulation*
  • Gene Silencing
  • Genome, Human
  • Heterogeneous-Nuclear Ribonucleoproteins / metabolism
  • Humans
  • Models, Genetic
  • RNA Precursors / genetics
  • RNA-Binding Proteins / genetics
  • RNA-Binding Proteins / metabolism
  • Ribonucleoproteins, Small Nuclear / genetics
  • Ribonucleoproteins, Small Nuclear / metabolism
  • Spliceosomes / genetics

Substances

  • Heterogeneous-Nuclear Ribonucleoproteins
  • RNA Precursors
  • RNA-Binding Proteins
  • Ribonucleoproteins, Small Nuclear