Abstract
Alternative splicing is typically thought to be controlled by RNA binding proteins that modulate the activity of the spliceosome. A new study not only demonstrates that alternative splicing can be regulated without the involvement of auxiliary splicing factors, but also provides mechanistic insight into how this can occur.
MeSH terms
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Alternative Splicing*
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Enhancer Elements, Genetic / genetics
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Exons
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Gene Expression Regulation*
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Gene Silencing
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Genome, Human
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Heterogeneous-Nuclear Ribonucleoproteins / metabolism
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Humans
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Models, Genetic
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RNA Precursors / genetics
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RNA-Binding Proteins / genetics
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RNA-Binding Proteins / metabolism
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Ribonucleoproteins, Small Nuclear / genetics
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Ribonucleoproteins, Small Nuclear / metabolism
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Spliceosomes / genetics
Substances
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Heterogeneous-Nuclear Ribonucleoproteins
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RNA Precursors
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RNA-Binding Proteins
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Ribonucleoproteins, Small Nuclear