Abstract
Genetic control of contact sensitivity to mercuric chloride antigen was studied using various strains on inbred mice. Mice with class II Ab,d,f,s haplotypes showed a high magnitude of response, whereas those with class II Ak,q were low responders. These results indicate that mercuric chloride contact sensitivity may be influenced by the I-A region of H-2. Transfer experiments revealed that these responses might be mediated by L3T4+, Lyt-2- T cells. However Lyt-2+ T cells do not suppress the DTH response.
MeSH terms
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Animals
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Antibodies, Monoclonal / immunology
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Dermatitis, Contact / etiology*
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Dermatitis, Contact / genetics
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Dermatitis, Contact / immunology
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H-2 Antigens / genetics
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H-2 Antigens / immunology*
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Histocompatibility Antigens Class II / genetics
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Histocompatibility Antigens Class II / immunology
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Hypersensitivity, Delayed / chemically induced
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Hypersensitivity, Delayed / genetics
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Hypersensitivity, Delayed / immunology
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Lymph Nodes / drug effects
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Lymph Nodes / immunology
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Lymph Nodes / pathology
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Mercuric Chloride / blood
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Mercuric Chloride / poisoning*
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Mice
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Mice, Inbred Strains
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T-Lymphocytes / immunology
Substances
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Antibodies, Monoclonal
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H-2 Antigens
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Histocompatibility Antigens Class II
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Mercuric Chloride