New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of alpha-lapachone derivatives under microwave irradiation

Ping Wei; Xiaohong Zhang; Shujiang Tu; Shu Yan; Hanjie Ying; Pingkai Ouyang

doi:10.1016/j.bmcl.2008.12.006

New potential inhibitors of DNA topoisomerase. Part II: Design and synthesis of alpha-lapachone derivatives under microwave irradiation

Bioorg Med Chem Lett. 2009 Feb 1;19(3):828-30. doi: 10.1016/j.bmcl.2008.12.006. Epub 2008 Dec 7.

Authors

Ping Wei¹, Xiaohong Zhang, Shujiang Tu, Shu Yan, Hanjie Ying, Pingkai Ouyang

Affiliation

¹ College of Life and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing, Jiangsu, 210009, PR China.

PMID: 19112020
DOI: 10.1016/j.bmcl.2008.12.006

Abstract

A new series of potential inhibitors of DNA topoisomerase II were synthesized from facile materials (aromatic aldehydes, Meldrum's acid and 2-hydroxynaphthalene-1,4-dione) under microwave irradiation. The method provides a valuable tool in designing new and more potent cytotoxic analogues. This procedure is advantageous both economically and environmentally.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antineoplastic Agents / pharmacology
Chemistry, Pharmaceutical / methods
Drug Design
Enzyme Inhibitors / chemistry
Enzyme Inhibitors / pharmacology*
Humans
Lactones / metabolism*
Magnetic Resonance Spectroscopy
Microwaves*
Models, Biological
Models, Chemical
Neoplasms / drug therapy
Solvents / chemistry
Temperature
Time Factors
Topoisomerase I Inhibitors*

Substances

Antineoplastic Agents
Enzyme Inhibitors
Lactones
Solvents
Topoisomerase I Inhibitors