Unholy matrimony: Aurora A and N-Myc as malignant partners in neuroblastoma

Cancer Cell. 2009 Jan 6;15(1):5-6. doi: 10.1016/j.ccr.2008.12.008.

Abstract

Aurora A is a mitotic kinase that is essential for regulation of the G2/M checkpoint. In this issue of Cancer Cell, Otto et al. report that Aurora A interacts with MYCN, a potent oncogene in human neuroblastoma, and sequesters it from proteolytic degradation. This surprising finding further enhances Aurora A's potential as a therapeutic target.

Publication types

  • Comment

MeSH terms

  • Animals
  • Aurora Kinases
  • Cell Cycle
  • Humans
  • Neuroblastoma / genetics
  • Neuroblastoma / metabolism*
  • Neuroblastoma / pathology
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism*
  • Proto-Oncogene Proteins c-myc / genetics
  • Proto-Oncogene Proteins c-myc / metabolism*

Substances

  • Proto-Oncogene Proteins c-myc
  • Aurora Kinases
  • Protein Serine-Threonine Kinases