Changes in aac(6')-Ib-cr prevalence and fluoroquinolone resistance in nosocomial isolates of Escherichia coli collected from 1991 through 2005

Antimicrob Agents Chemother. 2009 Mar;53(3):1268-70. doi: 10.1128/AAC.01300-08. Epub 2008 Dec 22.

Abstract

Clinical isolates of Escherichia coli collected from 1991 through 2005 at a tertiary-care center were studied for qnr and aac(6')-Ib-cr genes. Isolates bearing aac(6')-Ib-cr emerged in 1998, coinciding with an increase in ciprofloxacin resistance. The presence of aac(6')-Ib-cr was multiclonal and was associated with the presence of extended-spectrum beta-lactamases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology
  • Bacteremia / epidemiology
  • Bacteremia / microbiology
  • Cross Infection / genetics*
  • Drug Resistance, Bacterial*
  • Escherichia coli / genetics*
  • Escherichia coli / isolation & purification
  • Escherichia coli Infections / epidemiology
  • Escherichia coli Infections / microbiology
  • Fluoroquinolones / pharmacology
  • Genes, Bacterial*
  • Guidelines as Topic
  • Humans
  • Microbial Sensitivity Tests
  • Prevalence
  • Retrospective Studies
  • beta-Lactamases / genetics

Substances

  • Anti-Bacterial Agents
  • Fluoroquinolones
  • beta-Lactamases